Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia.

@article{Beucken2007RegulationOC,
  title={Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia.},
  author={Twan van den Beucken and Michael G Magagnin and Kim G. M. Savelkouls and Philippe Lambin and Marianne Koritzinsky and Bradly G. Wouters},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2007},
  volume={83 3},
  pages={346-52}
}
BACKGROUND AND PURPOSE Protein synthesis rates are greatly reduced under hypoxic conditions as a consequence of an overall inhibition of mRNA translation. Certain specific mRNA species have the ability to escape this general translational repression. At the cellular level this results in differential protein expression during hypoxic conditions. The… CONTINUE READING