Regulation of Cell Survival by Secreted Proneurotrophins

@article{Lee2001RegulationOC,
  title={Regulation of Cell Survival by Secreted Proneurotrophins},
  author={Ramee Lee and Pouneh Kermani and Kenneth K. Teng and Barbara L. Hempstead},
  journal={Science},
  year={2001},
  volume={294},
  pages={1945 - 1948}
}
Neurotrophins are growth factors that promote cell survival, differentiation, and cell death. They are synthesized as proforms that can be cleaved intracellularly to release mature, secreted ligands. Although proneurotrophins have been considered inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective matrix… 
Deciphering proneurotrophin actions.
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TLDR
Recent findings on the biological actions, regulation of expression, and pathophysiological effects of proneurotrophins will be reviewed.
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  • 2010
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Evidence that the proneurotrophin ligand-receptor system plays an important role in neuronal loss following seizures is discussed.
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In mature B cell lines, an autocrine BDNF production is up-regulated by stress culture conditions and exerts a modulation of apoptosis through the sortilin pathway, which could be of importance to elucidate certain drug resistances of malignant B cells.
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Arguments that the control of cell shape formation and cell selection can serve as an organizing principle of p75 signaling are presented, aimed at optimal morphological and functional integration of cells and cell populations into their context.
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TLDR
Results raise the intriguing possibility that dysregulation of proneurotrophin processing/release by innervated targets can be deleterious to the neurons projecting to these sites.
Pro-domain in precursor nerve growth factor mediates cell death
Role of Endogenous Brain-Derived Neurotrophic Factor and Sortilin in B Cell Survival1
TLDR
In mature B cell lines, an autocrine BDNF production is up-regulated by stress culture conditions and exerts a modulation of apoptosis through the sortilin pathway, which could be of importance to elucidate certain drug resistances of malignant B cells.
Neurotrophin survival signaling mechanisms.
TLDR
Difficulties in administering trophic factors have led to the consideration of using small molecules, such as G protein-coupled receptor (GPCR) ligands, which can participate in transactivation events.
Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor.
TLDR
The results indicate that furin determines the balance between proNGF and β-NGF in proliferating VSMCs, thus impacting on VSMC survival and migration and is also important in neointima formation.
Matrix Metalloproteinase-7 Regulates Cleavage of Pro-Nerve Growth Factor and Is Neuroprotective following Kainic Acid-Induced Seizures
TLDR
This study demonstrates that, following kainic acid-induced seizures, the proNGF processing enzyme matrix metalloproteinase 7 (MMP-7) and its inhibitor TIMP-1 are regulated in a manner that prevents proneurotrophin cleavage and leads to increased pro NGF in the extracellular milieu.
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