Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

@article{Takaishi1997RegulationOC,
  title={Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells },
  author={Kenji Takaishi and Takuya Sasaki and Hirokazu Kotani and Hideo Nishioka and Yoshimi Takai},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={139},
  pages={1047 - 1059}
}
The Rho small G protein family, consisting of the Rho, Rac, and Cdc42 subfamilies, regulates various cell functions, such as cell shape change, cell motility, and cytokinesis, through reorganization of the actin cytoskeleton. We show here that the Rac and Rho subfamilies furthermore regulate cell-cell adhesion. We prepared MDCK cell lines stably expressing each of dominant active mutants of RhoA (sMDCK-RhoDA), Rac1 (sMDCK-RacDA), and Cdc42 (sMDCK-Cdc42DA) and dominant negative mutants of Rac1… CONTINUE READING
Highly Influential
This paper has highly influenced 23 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 221 extracted citations

Role of Rho family GTPases in epithelial morphogenesis.

Genes & development • 2002
View 7 Excerpts
Highly Influenced

Cell adhesion and Rho small GTPases.

Journal of cell science • 1999
View 8 Excerpts
Highly Influenced

Signaling by Small GTPases at Cell-Cell Junctions: Protein Interactions Building Control and Networks.

Cold Spring Harbor perspectives in biology • 2018
View 2 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 75 references

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 5 Excerpts
Highly Influenced

Morphogenetic roles of classic cadherins.

Current opinion in cell biology • 1995
View 4 Excerpts
Highly Influenced

Microinjection of recombinant p21rho induces rapid changes in cell morphology

The Journal of cell biology • 1990
View 4 Excerpts
Highly Influenced

Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin.

Proceedings of the National Academy of Sciences of the United States of America • 1985
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…