Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients

Abstract

Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic compartments and loaded to major histocompatibility complex (MHC) class II molecules for CD4(+) T cell inspection. However, the processing and… (More)
DOI: 10.1371/journal.pone.0022815

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@inproceedings{Zou2011RegulationOC, title={Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients}, author={Fang Zou and Nadja Sch{\"a}fer and David Palesch and Ruth Br{\"u}cken and Alexander Beck and Marcin Sieńczyk and Hubert Kalbacher and Zilin Sun and Bernhard Otto Boehm and Timo Burster}, booktitle={PloS one}, year={2011} }