Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

@article{Hisanaga2009RegulationOC,
  title={Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic $\beta$-Cells},
  author={E. Hisanaga and M. Nagasawa and K. Ueki and R. Kulkarni and M. Mori and I. Kojima},
  journal={Diabetes},
  year={2009},
  volume={58},
  pages={174 - 184}
}
OBJECTIVE—Calcium-permeable cation channel TRPV2 is expressed in pancreatic β-cells. We investigated regulation and function of TRPV2 in β-cells. RESEARCH DESIGN AND METHODS—Translocation of TRPV2 was assessed in MIN6 cells and cultured mouse β-cells by transfecting TRPV2 fused to green fluorescent protein or TRPV2 containing c-Myc tag in the extracellular domain. Calcium entry was assessed by monitoring fura-2 fluorescence. RESULTS—In MIN6 cells, TRPV2 was observed mainly in cytoplasm in an… Expand
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