Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8

@article{Soete2006RegulationOC,
  title={Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8},
  author={Gwen A J Soete and Marco C. Betist and Hendrik C. Korswagen},
  journal={BMC Developmental Biology},
  year={2006},
  volume={7},
  pages={20 - 20}
}
In C. elegans and other nematode species, body size is determined by the composition of the extracellular cuticle as well as by the nuclear DNA content of the underlying hypodermis. Mutants that are defective in these processes can exhibit either a short or a long body size phenotype. Several mutations that give a long body size (Lon) phenotype have been characterized and found to be regulated by the DBL-1/TGF-β pathway, that controls post-embryonic growth and male tail development. Here we… CONTINUE READING

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The genetics of Caenorhabditis elegans

  • S Brenner
  • Genetics
  • 1974
Highly Influential
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