Regulation of Ca2+ homeostasis by islet endoplasmic reticulum and its role in insulin secretion.

@article{Wolf1988RegulationOC,
  title={Regulation of Ca2+ homeostasis by islet endoplasmic reticulum and its role in insulin secretion.},
  author={Bryan A. Wolf and Jerry Raymond Colca and Jed Turk and Jon R Florholmen and Michael L. McDaniel},
  journal={The American journal of physiology},
  year={1988},
  volume={254 2 Pt 1},
  pages={E121-36}
}
Changes in intracellular Ca2+ concentrations have a major role in the regulation of insulin secretion by islet beta-cells. It has recently become apparent that the endoplasmic reticulum plays a prominent role in the regulation of intracellular Ca2+ concentrations under basal conditions and during insulin secretion. This review describes biochemical… CONTINUE READING