Regulation of Ca(V)2 calcium channels by G protein coupled receptors.

  title={Regulation of Ca(V)2 calcium channels by G protein coupled receptors.},
  author={Gerald W Zamponi and Kevin P M Currie},
  journal={Biochimica et biophysica acta},
  volume={1828 7},
Voltage gated calcium channels (Ca²⁺ channels) are key mediators of depolarization induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of physiological responses. This review focuses on the inhibition of Ca(V)2 (N- and P/Q-type) Ca²⁺-channels by G protein coupled receptors (GPCRs), which exerts important autocrine/paracrine control over synaptic transmission and neuroendocrine secretion. Voltage-dependent inhibition is the most widespread mechanism, and… CONTINUE READING

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