Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.

@article{Gnerre2004RegulationOC,
  title={Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.},
  author={Carmela Gnerre and Sharon M Bl{\"a}ttler and Michel R Kaufmann and Renate Looser and Urs A. Meyer},
  journal={Pharmacogenetics},
  year={2004},
  volume={14 10},
  pages={
          635-45
        }
}
CYP3A4, the most abundant cytochrome P450 in human liver, is responsible for the metabolism of numerous xenobiotics and endobiotics. CYP3A4 expression is highly variable and is induced by numerous compounds of exogenous and endogenous origin, including elevated concentrations of secondary bile acids via the pregnane X receptor (PXR). We show that physiological concentrations of the primary bile acid chenodeoxycholic acid regulate the expression of CYP3A4 via the bile acid receptor FXR… Expand
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