Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2.

@article{Zhao2006RegulationOC,
  title={Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2.},
  author={Mingming Zhao and Richard G. Discipio and Antonia G. Wimmer and Ingrid U. Schraufstatter},
  journal={Molecular pharmacology},
  year={2006},
  volume={69 1},
  pages={66-75}
}
Activation of the chemokine receptor CXCR4 by its agonist stromal cell-derived factor 1 (SDF-1) has been associated with cell migration and proliferation in many cell types, but the intracellular signaling cascades are incompletely defined. Here we show that CXCR4-dependent extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation was mediated through the Ras/Raf pathway, as demonstrated with a dominant-negative Ras mutant and pharmacological inhibitors. The Src inhibitor 4-amino… CONTINUE READING
18 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…