Regulation of CRIg expression and phagocytosis in human macrophages by arachidonate, dexamethasone, and cytokines.

@article{Gorgani2011RegulationOC,
  title={Regulation of CRIg expression and phagocytosis in human macrophages by arachidonate, dexamethasone, and cytokines.},
  author={Nick N. Gorgani and Umaporn Thathaisong and Violet Rudo Mukaro and Ornnuthchar Poungpair and Amanda Tirimacco and Charles S. T. Hii and Antonio Ferrante},
  journal={The American journal of pathology},
  year={2011},
  volume={179 3},
  pages={
          1310-8
        }
}
Although the importance of the macrophage complement receptor immunoglobulin (CRIg) in the phagocytosis of complement opsonized bacteria and in inflammation has been established, the regulation of CRIg expression remains undefined. Because cellular activation during inflammation leads to the release of arachidonate, a stimulator of leukocyte function, we sought to determine whether arachidonate regulates CRIg expression. Adding arachidonate to maturing human macrophages and to prematured CRIg… CONTINUE READING

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