Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.

@article{Ginty1993RegulationOC,
  title={Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.},
  author={David D Ginty and Jon M. Kornhauser and Margaret A. Thompson and Hilmar Bading and Kelly E. Mayo and Joseph S Takahashi and Michael E. Greenberg},
  journal={Science},
  year={1993},
  volume={260 5105},
  pages={238-41}
}
Mammalian circadian rhythms are regulated by a pacemaker within the suprachiasmatic nuclei (SCN) of the hypothalamus. The molecular mechanisms controlling the synchronization of the circadian pacemaker are unknown; however, immediate early gene (IEG) expression in the SCN is tightly correlated with entrainment of SCN-regulated rhythms. Antibodies were isolated that recognize the activated, phosphorylated form of the transcription factor cyclic adenosine monophosphate response element binding… CONTINUE READING
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