Regulation of CRABP-II expression by MycN in Wilms tumor.

  title={Regulation of CRABP-II expression by MycN in Wilms tumor.},
  author={Anu Gupta and Patricia M Kessler and Jawhar Rawwas and Bryan R. G. Williams},
  journal={Experimental cell research},
  volume={314 20},
Cellular retinoic acid binding protein II (CRABP-II) is overexpressed in a wide variety of cancers. Previously we have shown that CRABP-II expression levels are also elevated in neuroblastoma and Wilms tumors. To elucidate the molecular mechanisms underlying the abnormal expression of CRABP-II in Wilms tumor, we studied the expression of MycN and CRABP-II in these tumor samples. Our data revealed that CRABP-II is overexpressed in Wilms tumor compared to normal adjacent non-neoplastic tissue and… CONTINUE READING
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