Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a

  title={Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a},
  author={Mary L Carlson and Ellen T Wilson and Stephen M. Prescott},
  journal={Molecular Cancer},
  pages={42 - 42}
Cyclooxygenase-2 (COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1. Recently shown to be essential for transformation via the c-Myc pathway, Pontin52/TIP49a promotes COX-2 expression in tissue culture and is… CONTINUE READING

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