Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms

  title={Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms},
  author={A. Naren and D. J. Nelson and W. Xie and B. Jovov and J. Pevsner and M. Bennett and D. Benos and M. Quick and K. Kirk},
  • A. Naren, D. J. Nelson, +6 authors K. Kirk
  • Published 1997
  • Biology, Medicine
  • Nature
  • The cystic fibrosis gene encodes a cyclic AMP-gated chloride channel (CFTR) that mediates electrolyte transport across the luminal surfaces of a variety of epithelial cells. The molecular mechanisms that modulate CFTR activity in epithelial tissues are poorly understood. Here we show that CFTR is regulated by an epithelially expressed syntaxin (syntaxin 1A), a membrane protein that also modulates neurosecretion and calcium-channel gating in brain. Syntaxin 1A physically interacts with CFTR… CONTINUE READING
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