Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease.

@article{Lu2008RegulationOC,
  title={Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease.},
  author={Linrong Lu and Hye-Jung Kim and Miriam Bianchi de Frontin Werneck and Harvey Cantor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 49},
  pages={19420-5}
}
Regulation of autoreactive CD4 T cells is essential to maintain self-tolerance and prevent autoimmune disease. Although CD8 T regulatory (Treg) cells that recognize self-peptides restricted by Qa-1 (HLA-E in humans) inhibit autoreactive CD4 cells and attenuate experimental autoimmune encephalomyelitis (EAE), the mechanism of this interaction is unclear. We… CONTINUE READING