Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host.

@article{Badovinac2003RegulationOC,
  title={Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host.},
  author={Vladimir P Badovinac and Kelly A. Nordyke Messingham and Sara E. Hamilton and John T Harty},
  journal={Journal of immunology},
  year={2003},
  volume={170 10},
  pages={4933-42}
}
Naive Ag-specific CD8(+) T cells expand, contract, and become memory cells after infection and/or vaccination. Memory CD8(+) T cells provide faster, more effective secondary responses against repeated exposure to the same pathogen. Using an adoptive transfer system with low numbers of trackable nontransgenic memory CD8(+) T cells, we showed that secondary responses can be comprised of both primary (naive) and secondary (memory) CD8(+) T cells after bacterial (Listeria monocytogenes) and/or… CONTINUE READING