Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA

@article{Siddiqa2001RegulationOC,
  title={Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA},
  author={Aisha Siddiqa and Jennifer Sims-Mourtada and Liliana Guzman-Rojas and Roberto Rangel and Christiane Guret and Vicente Madrid-Marina and Yan Sun and Hector Martinez-Valdez},
  journal={Nature},
  year={2001},
  volume={410},
  pages={383-387}
}
Proteins containing AT hooks bind A/T-rich DNA through a nine-amino-acid motif and are thought to co-regulate transcription by modifying the architecture of DNA, thereby enhancing the accessibility of promoters to transcription factors. Here we describe AKNA, a human AT-hook protein that directly binds the A/T-rich regulatory elements of the promoters of CD40 and CD40 ligand (CD40L) and coordinately regulates their expression. Consistent with its function, AKNA is a nuclear protein that… CONTINUE READING