Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia

@article{Schwarzmeier2005RegulationOC,
  title={Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia},
  author={J. Schwarzmeier and R. Hubmann and M. Duechler and U. Jaeger and M. Shehata},
  journal={Leukemia & Lymphoma},
  year={2005},
  volume={46},
  pages={157 - 165}
}
  • J. Schwarzmeier, R. Hubmann, +2 authors M. Shehata
  • Published 2005
  • Medicine
  • Leukemia & Lymphoma
  • The original observation that sera from patients with chronic B-cell lymphocytic leukemia (B-CLL) contain high amounts of soluble CD23 (sCD23), which reflect disease activity and tumor load has been confirmed by numerous reports and serial determinations of sCD23 are now recognized as important indicators of disease progression. The reason why the leukemic cells over express CD23 and subsequently release large quantities of sCD23 as compared to healthy persons or patients with other… CONTINUE READING
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