Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells.

@article{Li2004RegulationOC,
  title={Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells.},
  author={Chenwei Li and Xuequn Chen and John A. Williams},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={287 4},
  pages={G764-71}
}
PKC is known to be activated by pancreatic secretagogues such as CCK and carbachol and to participate along with calcium in amylase release. Four PKC isoforms, alpha, delta, epsilon, and zeta, have been identified in acinar cells, but which isoforms participate in amylase release are unknown. To identify the responsible isoforms, we used translocation assays, chemical inhibitors, and overexpression of individual isoforms and their dominant-negative variants by means of adenoviral vectors. CCK… CONTINUE READING