Regulation of Brucella virulence by the two-component system BvrR/BvrS.

@article{LpezGoi2002RegulationOB,
  title={Regulation of Brucella virulence by the two-component system BvrR/BvrS.},
  author={Ignacio L{\'o}pez-Go{\~n}i and Caterina Guzm{\'a}n-Verri and Lorea Manterola and Alberto Sola-Landa and Ignacio Moriy{\'o}n and Edgardo Moreno},
  journal={Veterinary microbiology},
  year={2002},
  volume={90 1-4},
  pages={329-39}
}
The Brucella BvrR/BvrS two-component regulatory system is highly similar to the regulatory and sensory proteins of Sinorhizobium and Agrobacterium necessary for endosymbiosis and pathogenicity in plants, and very similar to a putative system present in the animal pathogen Bartonella. Mutations in the bvrR or bvrS genes hamper the penetration of B. abortus in non-phagocytic cells and impairs intracellular trafficking and virulence. In contrast to virulent Brucella, BvrR/BvrS mutants do not… CONTINUE READING

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