Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking

@article{Henderson2005RegulationOB,
  title={Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking},
  author={Beric R. Henderson},
  journal={BioEssays},
  year={2005},
  volume={27}
}
  • B. Henderson
  • Published 1 September 2005
  • Biology, Medicine
  • BioEssays
The subcellular location and function of many proteins are regulated by nuclear–cytoplasmic shuttling. BRCA1 and BARD1 provide an interesting model system for understanding the influence of protein dimerization on nuclear transport and localization. These proteins function predominantly in the nucleus to regulate cell cycle progression, DNA repair/recombination and gene transcription, and their export to the cytoplasm has been linked to apoptosis. Germ‐line mutations in the BRCA1/BRCA2 and… 
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It is shown that both N and C termini of BRCA1 are required for its centrosomal localization and that B RCA1 moves to the centrosome independently of BARD1 and γ-tubulin.
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TLDR
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It is shown that HERC2, a protein recently implicated in DNA damage repair, targets BARD1-uncoupled BRCA1 for degradation, and that herC2 depletion antagonizes the effects of Bard1 depletion by restoring BRCa1 expression and G(2)-M checkpoint activity.
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TLDR
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TLDR
This review work aims at presenting the major efforts focused on the functional characterization and structural insights of BRCA1 and BARD1, per se and in combination with all their principal mediators and regulators, and on the multifaceted roles these proteins play in the maintenance of human genome integrity.
BARD1 regulates BRCA1-mediated transactivation of the p21WAF1/CIP1 and Gadd45 promoters.
TLDR
It is proposed that BARD1 reduces BRCA1 transcriptional activity, and that this at least partly involves B RCA1/BARD1 E3 ubiquitin ligase activity, which is disrupted by the C61G mutation.
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  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
It is shown that the steady-state levels of BARD1, unlike those of BRCA1, remain relatively constant during cell cycle progression, and this cell cycle-dependent colocalization of Bard1 and BRC a1 indicates a role for BARD 1 in BRCa1-mediated tumor suppression.
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TLDR
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TLDR
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TLDR
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