Regulation of BMP/Dpp signaling during embryonic development

  title={Regulation of BMP/Dpp signaling during embryonic development},
  author={Takeo Nakayama and Yazhou Cui and Jan L Christian},
  journal={Cellular and Molecular Life Sciences CMLS},
Bone morphogenetic protein-4 (BMP-4) and its Drosophila ortholog, decapentaplegic (Dpp), are multifunctional developmental regulators. Both gain-of-function and loss-of-function studies demonstrate that the biological activity and signaling range of these morphogens must be strictly regulated to ensure normal embryonic patterning. BMP-4 and Dpp are produced from inactive precursors that are proteolytically cleaved, following which the active ligand is secreted into the extracellular space… CONTINUE READING
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