Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma.

  title={Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma.},
  author={Isabella Eckerle and Daniel R Muth and Julia Batzler and Kai-Oliver Henrich and Werner Lutz and Matthias Hermann Fischer and Olaf Witt and Manfred Schwab and Frank Westermann},
  journal={Cancer letters},
  volume={285 1},
We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of both transcripts was stage-dependent, associated with poor prognosis and with the expression of the transcription factor E2F1. In cell culture, we identified BIRC5 as a direct transcriptional target of activating E2Fs, primarily when p21(Cip1) and p27(Kip1), two other E2F1 targets, are strongly… CONTINUE READING
Highly Cited
This paper has 30 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…