Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma.

@article{Eckerle2009RegulationOB,
  title={Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma.},
  author={Isabella Eckerle and Daniel R Muth and Julia Batzler and Kai-Oliver Henrich and Werner Lutz and Matthias Hermann Fischer and Olaf Witt and Manfred Schwab and Frank Westermann},
  journal={Cancer letters},
  year={2009},
  volume={285 1},
  pages={99-107}
}
We analysed the expression of BIRC5 and BIRC5-2B in primary neuroblastoma (NB) tumors and NB model systems. In tumors, overexpression of BIRC5 correlated closely with its isoform BIRC5-2B. Expression of both transcripts was stage-dependent, associated with poor prognosis and with the expression of the transcription factor E2F1. In cell culture, we identified BIRC5 as a direct transcriptional target of activating E2Fs, primarily when p21(Cip1) and p27(Kip1), two other E2F1 targets, are strongly… CONTINUE READING
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