Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast.

@article{Amon1997RegulationOB,
  title={Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast.},
  author={Angelika Amon},
  journal={The EMBO journal},
  year={1997},
  volume={16 10},
  pages={2693-702}
}
In budding yeast, stability of the mitotic B-type cyclin Clb2 is tightly cell cycle-regulated. B-type cyclin proteolysis is initiated during anaphase and persists throughout the G1 phase. Cln-Cdc28 kinase activity at START is required to repress B-type cyclin-specific proteolysis. Here, we show that Clb-dependent kinases, when expressed during G1, are also capable of repressing the B-type cyclin proteolysis machinery. Furthermore, we find that inactivation of Cln- and Clb-Cdc28 kinases is… CONTINUE READING