Regulation of B-cell growth and differentiation by soluble factors.

  title={Regulation of B-cell growth and differentiation by soluble factors.},
  author={Maureen Howard and William E. Paul},
  journal={Annual review of immunology},
The B-lymphocyte family of cells presents one of the most remarkable opportunities for the detailed study of regulation of growth and differentiation. Some members of this cell population have the property that they may be stimulated by ligand-receptor interactions, together with the sequential action of a series of lymphokines, to progress from the resting state, through several rounds of proliferation, and then to differentiate to immunoglobulin secretion. Other cells in this group… CONTINUE READING

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