Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway.

@article{Marshall2000RegulationOB,
  title={Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway.},
  author={Aaron J Marshall and Hiroaki Niiro and Theodore J. Yun and Edward A. Clark},
  journal={Immunological reviews},
  year={2000},
  volume={176},
  pages={30-46}
}
Signal transduction through the B-cell antigen receptor (BCR) determines the fate of B lymphocytes during their development and during immune responses. A multitude of signal transduction events are known to be activated by ligation of the BCR; however, the critical parameters determining the biological outcome of the signal transduction cascade are only just beginning to be understood. Two enzymes which act on plasma membrane phospholipids, phosphatidylinositol 3-kinase (PI3K) and… CONTINUE READING

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