Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells.

@article{Poulaki2002RegulationOA,
  title={Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells.},
  author={Vassiliki Poulaki and Constantine Mitsiades and Vassiliki Kotoula and Sophia Tseleni-Balafouta and Azaria Ashkenazi and Demetrios A. Koutras and Nicholas S Mitsiades},
  journal={The American journal of pathology},
  year={2002},
  volume={161 2},
  pages={
          643-54
        }
}
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/Apo2 ligand selectively kills neoplastic cells, including thyroid carcinoma cells (Mitsiades et al: Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 2000, 60:4122-41299). We investigated the mechanisms regulating Apo2L/TRAIL-induced apoptosis in thyroid carcinoma cells, as well as the impact of insulin-like growth factor (IGF… CONTINUE READING
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