Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling

Abstract

Proteolytic processing of the amyloid precursor protein (APP) by the β- and γ-secretases releases the amyloid-β peptide (Aβ), which deposits in senile plaques and contributes to the etiology of Alzheimer's disease (AD). The α-secretase cleaves APP in the Aβ peptide sequence to generate soluble APPα (sAPPα). Upregulation of α-secretase activity through the 5… (More)
DOI: 10.1371/journal.pone.0087014

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