Regulation of Alström syndrome gene expression during adipogenesis and its relationship with fat cell insulin sensitivity.

@article{Romano2008RegulationOA,
  title={Regulation of Alstr{\"o}m syndrome gene expression during adipogenesis and its relationship with fat cell insulin sensitivity.},
  author={Sara Romano and Gabriella Milan and Caterina Veronese and Gayle B Collin and Jan Davis Marshall and Cinzia Centobene and Francesca Favaretto and Chiara Dal Pr{\`a} and Alessandro Scarda and Sonia Leandri and J{\"u}rgen K Naggert and Pietro Maffei and Roberto Vettor},
  journal={International journal of molecular medicine},
  year={2008},
  volume={21 6},
  pages={731-6}
}
Alström syndrome (ALMS) is an autosomal recessive genetic disease with characteristic phenotypical features including multi-organ fibrosis, insulin resistance, obesity and type 2 diabetes. ALMS1, a ubiquitously expressed gene mutated in ALMS patients, gives rise to a protein of unknown function localized to basal bodies of ciliated cells and centrosomes. Together with Bardet-Biedl syndrome, ALMS is a member of genetic ciliopathies, but the link between cilia/centrosome deficits and metabolic… CONTINUE READING