Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo.

@article{Beaulieu2007RegulationOA,
  title={Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo.},
  author={J E Beaulieu and Emanuele Tirotta and Tatyana D. Sotnikova and Bernard Masri and Ali Salahpour and Raul R Gainetdinov and Emiliana Borrelli and Marc G. Caron},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 4},
  pages={881-5}
}
The serine/threonine kinase Akt is a downstream target of dopamine receptor signaling that is inhibited/dephosphorylated in response to direct and indirect dopamine receptor agonists. Although pharmacological studies uncovered the involvement of D2-class dopamine receptors in Akt regulation, they did not identify the role of individual receptor subtypes in… CONTINUE READING