Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.

Abstract

Abro1 (also known as KIAA0157) is a scaffold protein that recruits polypeptides to assemble the BRISC (BRCC36-containing isopeptidase complex) deubiquitinating (DUB) enzyme. The four subunits of BRISC enzyme include Abro1, NBA1, BRE, and BRCC36 proteins. The DUB activity of the BRISC enzyme is exclusively directed against Lys63-linked polyubiquitin that… (More)
DOI: 10.1016/j.yjmcc.2010.12.015

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Cite this paper

@article{Cilenti2011RegulationOA, title={Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination.}, author={Lucia Cilenti and Meenakshi P Balakrishnan and Xiao-Liang Wang and Camilla T Ambivero and Martin Sterlicchi and Federica del Monte and Xin Ma and Antonis S. Zervos}, journal={Journal of molecular and cellular cardiology}, year={2011}, volume={50 4}, pages={652-61} }