Regulation of APC/C activators in mitosis and meiosis.

  title={Regulation of APC/C activators in mitosis and meiosis.},
  author={Jillian A Pesin and Terry L Orr-Weaver},
  journal={Annual review of cell and developmental biology},
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and Cdh1/Fizzy-related activate the APC/C and confer substrate specificity through complex interactions with both the core APC/C and substrate proteins. The regulation of Cdc20 and Cdh1 is critical for proper APC/C activity and occurs in multiple ways: targeted protein degradation, phosphorylation, and direct binding of… CONTINUE READING
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