Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation

@inproceedings{Lin2009RegulationOA,
  title={Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation},
  author={Da–Ting Lin and Yuichi Makino and Kamal Sharma and Takashi Hayashi and Rachael Lee Neve and Kogo Takamiya and Richard L. Huganir},
  booktitle={Nature Neuroscience},
  year={2009}
}
The insertion of AMPA receptors (AMPARs) into the plasma membrane is an important step in the synaptic delivery of AMPARs during the expression of synaptic plasticity. However, the molecular mechanisms regulating AMPAR insertion remain elusive. By directly visualizing individual insertion events of the AMPAR subunit GluR1 in rodents, we found that the protein 4.1N was required for activity-dependent GluR1 insertion. Protein kinase C (PKC) phosphorylation of the serine 816 (S816) and S818… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 50 references

The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression

C Wozny
J Cell Sci 122, • 2009

Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2007

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