Regulation of AMPA Receptor Trafficking in the Nucleus Accumbens by Dopamine and Cocaine

@article{Wolf2010RegulationOA,
  title={Regulation of AMPA Receptor Trafficking in the Nucleus Accumbens by Dopamine and Cocaine},
  author={Marina E Wolf},
  journal={Neurotoxicity Research},
  year={2010},
  volume={18},
  pages={393-409}
}
Nucleus accumbens (NAc) neurons are excited primarily by AMPA-type glutamate receptors (AMPAR). This is required for cocaine seeking in animal models of cocaine addiction, suggesting AMPAR transmission in the NAc as a key control point for cocaine-related behaviors. This review will briefly describe AMPAR properties and trafficking, with a focus on studies in NAc neurons, and then consider mechanisms by which cocaine may alter AMPAR transmission. Two examples will be discussed that may be… CONTINUE READING

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