Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.

@article{Wilson2003RegulationOA,
  title={Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.},
  author={Gerald M. Wilson and Jiebo Lu and Kristina Sutphen and Yue Sun and Yung Huynh and Gary Brewer},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={33029-38}
}
Proteins binding A + U-rich elements (AREs) contribute to the rapid cytoplasmic turnover of mRNAs containing these sequences. However, this process is a regulated event and may be accelerated or inhibited by myriad signal transduction systems. For example, monocyte adherence at sites of inflammation or tissue injury is associated with inhibition of ARE-directed mRNA decay, which contributes to rapid increases in cytokine and inflammatory mediator production. Here, we show that acute exposure of… CONTINUE READING
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