Regulation of 5-HT release from enterochromaffin cells

@article{Rack1995RegulationO5,
  title={Regulation of 5-HT release from enterochromaffin cells},
  author={Kurt Rack{\'e} and Andreas Reimann and Harald Schw{\"o}rer and Heinz J. Kilbinger},
  journal={Behavioural Brain Research},
  year={1995},
  volume={73},
  pages={83-87}
}
Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro
TLDR
It is found that stimulatory 5-HT3 and inhibitory 5- HT4 receptors are present on enterochromaffin cells of the porcine and human intestinal mucosa and under the present experimental conditions endogenous5-HT does not significantly activate these receptors.
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
TLDR
It is demonstrated that the transient receptor potential (TRP) cation channel TRPA1, which is activated by pungent compounds or cold temperature, is highly expressed in EC cells, and that allyl isothiocyanate promotes the contraction of isolated guinea pig ileum via the 5-HT3 receptor.
Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model.
TLDR
Tonic or mechanically evoked release of endogenous adenosine is a critical determinant of differential activation ofAdenosine receptors and may have important implications for gut mechanosensory reflexes.
Investigation into the 5-hydroxytryptophan-evoked luminal 5-hydroxytryptamine release from the guinea pig colon.
TLDR
It is concluded that in the guinea pig colon, 5-HTP facilitates the luminal 5- HT release from EC cells, with no involvement of neuronal mechanisms and a non-neuronal cholinergic system.
NK1- and NK3-receptor mediated inhibition of 5-hydroxytryptamine release from the vascularly perfused small intestine of the guinea-pig
TLDR
The release of 5-HT from enterochromaffin cells is directly inhibited by NK1 receptors, and indirectly by neuronal NK3 receptors whose stimulation leads to the release of SP.
THE EFFECTS OF SEROTONIN RECEPTOR ANTAGONISTS ON CONTRACTION AND RELAXATION RESPONSES INDUCED BY ELECTRICAL STIMULATION IN THE RAT SMALL INTESTINE
TLDR
EFS-induced responses were sensitive to TTX and partly to atropine, indicating a major neuronal involvement and a cholinergic system, which suggests the unlikely involvement of endogenous 5-HT in mediating responses to EFS in the described test conditions.
Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.
TLDR
A fundamental role for 5-HT as an intrinsic cofactor in T-cell activation and function is demonstrated and an alternative mechanism through which immune function may be regulated by indoleamine 2,3-dioxygenase-mediated catabolism of tryptophan is suggested.
Serotonin release and uptake in the gastrointestinal tract
Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis.
TLDR
Changes in enteroendocrine cell populations and 5-HT availability could contribute to the altered motility and secretion associated with intestinal inflammation by disrupting mucosal signaling to enteric nerves involved in peristaltic and secretory reflexes.
Role of neuropeptide-sensitive L-type Ca2+ channels in histamine release in gastric enterochromaffin-like cells.
TLDR
K+- or TEA+-dependent effects on histamine release from ECL cells were coupled to activation of parietal cells in intact rabbit gastric glands, and L-type channel blockade by 2 μM nifedipine inhibited 50% of [Ca2+]i elevation and histamines release.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
Regulation of serotonin release from rabbit intestinal enterochromaffin cells.
  • E. Forsberg, R. Miller
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1983
TLDR
Rabbit enterochromaffin cells located in the mucosal epithelium of the small intestine were studied in vitro and potential roles for both calcium and cyclic nucleotides in the regulation of serotonin release are suggested.
Adrenergic modulation of the release of 5‐hydroxytryptamine from the vascularly perfused ileum of the guinea‐pig
TLDR
The β‐adrenoceptor‐mediated effect on 5‐HT release appears to involve an increase in cyclic AMP, as the effect of isoprenaline was potentiated after inhibition of phosphodiesterase.
Distribution, properties, and functional characteristics of three classes of histamine receptor.
  • S. Hill
  • Biology, Medicine
    Pharmacological reviews
  • 1990
It is clear from the preceding overview of histamine receptor pharmacology that research into the pharmacology of histamine receptors is at an exciting stage of development. The rapid advance of
Stimulation of Intestinal Adenyl Cyclase by Cholera Toxin
TLDR
The toxin might stimulate secretory transport processes, for example Cl− and HCO−3, to such an extent that reabsorptive capacity is exceeded, water is held osmotically and massive diarrhoea results.
...
1
2
...