Regulation of 5-HT receptors by corticosteroids: where do we stand?

@article{Chaouloff1995RegulationO5,
  title={Regulation of 5-HT receptors by corticosteroids: where do we stand?},
  author={Francis Chaouloff},
  journal={Fundamental & clinical pharmacology},
  year={1995},
  volume={9 3},
  pages={219-33}
}
Twenty five years ago, experimental procedures such as adrenalectomy and corticosteroid administration (to intact rats) allowed the recognition of direct and indirect controls of central 5-HT synthesis rate by corticosteroids. These effects indicated that the activity of the hypothalamo-pituitary-adrenal (HPA) axis, whether under basal conditions or during stress, is endowed with a modulatory action upon serotonergic neurons. Nowadays, in situ hybridisation, in vitro autoradiography, and… CONTINUE READING