Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases.

@article{Awasthi2004RegulationO4,
  title={Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases.},
  author={Y. Awasthi and Yusong Yang and N. K. Tiwari and B. Patrick and Abha Sharma and J. Li and S. Awasthi},
  journal={Free radical biology \& medicine},
  year={2004},
  volume={37 5},
  pages={
          607-19
        }
}
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. Glutathione S-transferases (GSTs) can modulate the intracellular concentrations of HNE by affecting its generation during lipid peroxidation by reducing hydroperoxides and also by converting it into a glutathione conjugate. We have recently demonstrated that… Expand
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  • A. Rinna, H. J. Forman
  • Biology, Medicine
  • American journal of respiratory cell and molecular biology
  • 2008
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