Regulation of 3' IgH enhancers by a common set of factors, including kappa B-binding proteins.

@article{Michaelson1996RegulationO3,
  title={Regulation of 3' IgH enhancers by a common set of factors, including kappa B-binding proteins.},
  author={Jennifer S. Michaelson and Mallika Singh and Clifford M Snapper and William C. Sha and David Baltimore and Barbara K. Birshtein},
  journal={Journal of immunology},
  year={1996},
  volume={156 8},
  pages={2828-39}
}
Targeted disruption of the p50 subunit of NF-kappa B resulted in isotype class switch defects resembling those observed in mice in which the downstream IgH enhancer 3'alpha E(hs1,2) was deleted. We postulated that kappa B binding proteins may regulate class switching by interacting with 3'alpha E(hs1,2) or with other IgH 3' enhancers with which 3'alpha E(hs1,2) synergizes. kappa B binding sites were identified in 3'alpha E(hs1,2) and 3' alpha-hs4, the distal 3' IgH enhancer. A kappa B binding… CONTINUE READING

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