Regulation of 25-hydroxyvitamin D-1alpha-hydroxylase by epidermal growth factor in prostate cells.

@article{Wang2004RegulationO2,
  title={Regulation of 25-hydroxyvitamin D-1alpha-hydroxylase by epidermal growth factor in prostate cells.},
  author={Lilin Wang and John N. Flanagan and Lyman W Whitlatch and Daniel P Jamieson and Michael F Holick and Tai Chih Chen},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2004},
  volume={89-90 1-5},
  pages={127-30}
}
Accumulating data suggest that local production of 1alpha,25-dihydroxyvitamin D (1alpha,25(OH)(2)D) could provide an important cell growth regulatory mechanism in an autocrine fashion in prostate cells. Previously, we demonstrated a differential expression of 1alpha-OHase enzymatic activity among noncancerous (PZHPV-7) and cancer cells (PC-3, DU145, LNCaP), which appears to correlate with 1alpha-OHase m-RNA synthesis and its promoter activities. Since it is well-established that EGF regulates… CONTINUE READING