Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells.

@article{Pasquarette1996RegulationO1,
  title={Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity and mRNA in human choriocarcinoma cells.},
  author={M M Pasquarette and P. M. Stewart and Marie Louise Ricketts and Kozue Imaishi and James Ian Mason},
  journal={Journal of molecular endocrinology},
  year={1996},
  volume={16 3},
  pages={269-75}
}
The type 2 isoform of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD2), which catalyzes the conversion of cortisol to hormonally inactive cortisone in man, is principally expressed in the placenta and mineralocorticoid target tissues, kidney and colon. To date, few studies have addressed the regulation of this novel 11 beta-HSD2 isoform. We have characterized the nature and regulation of the 11 beta-HSD activity expressed in a human cytotrophoblastic cell line, the JEG-3 choriocarcinoma cell… CONTINUE READING

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