Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in ovine placenta by fetal cortisol.

@article{Clarke2002RegulationO1,
  title={Regulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in ovine placenta by fetal cortisol.},
  author={Kimberley A. Clarke and Janelle W Ward and Alison J Forhead and Dino A Giussani and Abigail L Fowden},
  journal={The Journal of endocrinology},
  year={2002},
  volume={172 3},
  pages={527-34}
}
The effect of fetal cortisol on the activity of the type 2 isoform of the enzyme, 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD2), was examined in ovine placenta and fetal kidney by measuring tissue 11 beta-HSD2 activity during late gestation when endogenous fetal cortisol levels rise and after exogenous cortisol administration to immature fetuses before the prepartum cortisol surge. Placental 11 beta-HSD2 activity decreased between 128-132 days and term (approximately 145 days of gestation… CONTINUE READING

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