Regulation of 1,25-dihydroxyvitamin d synthesis by intracellular vitamin d binding protein-1.

@article{Wu2002RegulationO1,
  title={Regulation of 1,25-dihydroxyvitamin d synthesis by intracellular vitamin d binding protein-1.},
  author={Shaoxing Wu and Rene F. Chun and Mercedes A. Gacad and Songyang Ren and Hong Chen and John S Adams},
  journal={Endocrinology},
  year={2002},
  volume={143 10},
  pages={4135}
}
Control of 125-dihydroxyvitamin D (1,25-(OH)2D) synthesis is believed to be primarily at the level of expression of the vitamin D-1-hydroxylase (CYP1alpha; CYP1alpha) gene. Once transcribed, generation of product, as catalyzed by 1-hydroxylase, depends upon the availability of various co-factors, molecular oxygen, electrons as well as substrate to the enzyme. Here we provide evidence that the quantity of product 1,25-(OH)2D generated also relies on the presence and level of expression of the… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…