Regulation mechanisms and signaling pathways of autophagy.

  title={Regulation mechanisms and signaling pathways of autophagy.},
  author={Congcong He and Daniel J Klionsky},
  journal={Annual review of genetics},
Autophagy is a process of self-degradation of cellular components in which double-membrane autophagosomes sequester organelles or portions of cytosol and fuse with lysosomes or vacuoles for breakdown by resident hydrolases. Autophagy is upregulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation, ER stress, and pathogen infection. Defective autophagy plays a significant role in human pathologies, including cancer, neurodegeneration, and… CONTINUE READING