Regulation from within: the cytoskeleton in transmembrane signaling.

@article{Jaqaman2012RegulationFW,
  title={Regulation from within: the cytoskeleton in transmembrane signaling.},
  author={Khuloud Jaqaman and Sergio Grinstein},
  journal={Trends in cell biology},
  year={2012},
  volume={22 10},
  pages={515-26}
}
There is mounting evidence that the plasma membrane is highly dynamic and organized in a complex manner. The cortical cytoskeleton is proving to be a particularly important regulator of plasmalemmal organization, modulating the mobility of proteins and lipids in the membrane, facilitating their segregation, and influencing their clustering. This organization plays a critical role in receptor-mediated signaling, especially in the case of immunoreceptors, which require lateral clustering for… CONTINUE READING
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