Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes.

@article{Busch1992RegulationBS,
  title={Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes.},
  author={Andreas E. Busch and Michael P. Kavanaugh and Michael D. Varnum and John P Adelman and R Alan North},
  journal={The Journal of physiology},
  year={1992},
  volume={450},
  pages={
          491-502
        }
}
1. Voltage-clamp recordings of membrane current were made from Xenopus oocytes that had been injected with RNA which had been transcribed in vitro from a cloned complementary DNA. 2. Depolarization from -80 mV evoked outward potassium currents that developed very slowly. At -20 mV the time constant for activation was about 50 s, and at +40 mV about 6 s. 3. The potassium current was increased by the calcium ionophore A23187 or by intracellular injection of inositol 1,4,5-trisphosphate (IP3… CONTINUE READING

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