Regulation by proteolysis: developmental switches.

  title={Regulation by proteolysis: developmental switches.},
  author={Susan Gottesman},
  journal={Current opinion in microbiology},
  volume={2 2},
The energy-dependent proteases originally defined in Escherichia coli have proven to have particularly important roles in bacterial developmental systems, including sporulation in Bacillus subtilis and cell cycle in Caulobacter. Degradation of key regulatory proteins participates, with regulation of synthesis and activity of the regulators, to ensure tight control and, where required, irreversible commitment of the cell to specific developmental pathways.