Regulation by nitric oxide of prostaglandin E synthesis and spontaneous motility in rat uterine tissue.

@article{Motta1998RegulationBN,
  title={Regulation by nitric oxide of prostaglandin E synthesis and spontaneous motility in rat uterine tissue.},
  author={Alicia Beatriz Motta and M A Chaud and M A F de Gimeno},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1998},
  volume={58 5},
  pages={333-8}
}
We explored the role of endogenous nitric oxide (NO) in the spontaneous motility of uterine tissue from pseudopregnant (psp) rats and the correlation between this action and the uterotonic prostaglandin (PG) E production. We worked in the early psp (on day 5 of psp), and in late psp (on day 8 and day 9). Treatment with N(G)-monomethyl-L-arginine L-NMMA (300 microM), a competitive nitric oxide synthase (NOS) inhibitor, did not modify isometric developed tension (IDT) and frequency of… CONTINUE READING

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