Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers

@article{Wesson2004RegulationBM,
  title={Regulation by macromolecules of calcium oxalate crystal aggregation in stone formers},
  author={Jeffrey A Wesson and Vincent Ganne and Ann M. Beshensky and Jack G. Kleinman},
  journal={Urological Research},
  year={2004},
  volume={33},
  pages={206-212}
}
Based on the structure of kidney stones, it is likely that they form as aggregations of preformed crystals, mostly calcium oxalate monohydrate (COM). In this study, we examined the ability of a macromolecular mixture isolated from the urine of normal individuals and stone formers to inhibit aggregation of preformed COM seed crystals in a simple ionic solution using measurements of changes in the particle size distribution (PSD) of preformed COM crystal aggregates. We also examined the effect in… CONTINUE READING